Semantic analysis of multimedia content is an on going research area that has gained a lot of attention over the last few years. Additionally, machine learning techniques are widely used for multimedia analysis with great success. This work presents a combined approach to semantic adaptation of neural network classifiers in multimedia framework. It is based on a fuzzy reasoning engine which is able to evaluate the outputs and the confidence levels of the neural network classifier, using a knowledge base. Improved image segmentation results are obtained, which are used for adaptation of the network classifier, further increasing its ability to provide accurate classification of the specific content.