In the development of actual application, Ethernet and CAN bus are used very extensively. Owing to its various communication protocols, the communicating between two kinds of bus device can’t be carried out. Therefore, in order to solve this problem, the Ethernet-CAN bus interface circuit based on CP2200 and C8051F040 was designed in this paper, and part of the related hardware circuit and software design analysis were given. On the condition of data’s integrity and protocols’reliability, through the handshaking protocols and the simplified the Ethernet protocol, not only the data switching between CAN and Ethernet was realized, but also the differ in velocity and packet size was solved.